Observed in #24827 (https://cirrus-ci.com/task/6466255107391488) but very likely unrelated. Looks to me that a testmempoolaccept RPC call issued by the mini-wallet timed out - so it seems that it occurs after the #24817 rework but has a root cause in bitcoind?
0 node1 2022-04-11T17:04:58.456117Z [httpworker.3] [rpc/request.cpp:179] [parse] ThreadRPCServer method=testmempoolaccept user=__cookie__
1 node1 2022-04-11T17:05:25.635870Z [msghand] [net.cpp:3041] [PushMessage] sending ping (8 bytes) peer=0
2 node1 2022-04-11T17:06:50.669591Z [scheduler] [random.cpp:520] [SeedPeriodic] Feeding 32422 bytes of dynamic environment data into RNG
3 node0 2022-04-11T17:06:50.669699Z [net] [net.cpp:1651] [SocketHandlerConnected] socket closed for peer=1
4 node0 2022-04-11T17:06:50.671075Z [net] [net.cpp:567] [CloseSocketDisconnect] disconnecting peer=1