Should fix #6436. See here for more info. Also the source is self-explanatory.
Since we don't use any loadable functionality, I don't see how this could hurt. Presumably qt tries to load available modules, but the fallbacks should always work.
One last data point: The depends build is trying to load /home/ubuntu/build/bitcoin/depends/x86_64-unknown-linux-gnu/etc/openssl/openssl.cnf which obviously won't be found in the end-user's environment. So this functionality has actually been disabled for a long time anyway.