Bitcoin 0.11 on a Raspberry Pi 2
From the command line, bitcoin-cli getnewaddress can take up to 1 minute to respond.
When using jgarzik's python bitcoin RPC module to make this RPC call, it often times out.
Sometimes after it times-out on getnewaddress, even stranger behavior follows: getmempoolinfo reports NO INCREASE in mempool size until the original script that timed-out is interrupted and killed. Even when requesting bitcoin-cli getmempoolinfo from a separate terminal session, without the python RPC module.
bitcoin-cli dumpwallet still responds immediately. Wallet is unencrypted, only 100 keys, only 327kB