Our test framework's EC key wrapper (qa/rpc-tests/test_framwork/key.py) doesn't support a way to enforce low-S use in signatures. This is an annoyance when writing tests for mempool acceptance, as our standardness rules now enforce low-S.
If someone wants to improve this, it would be nice to add an interface that would allow us to explicitly choose a low-S or high-S signature (either when signing, or as a separate function that would do the conversion).