Adding U to the magic constants ensures that we are not mixing unsigned and signed value during multiplication, and ensures that the multiplication will not be subject to integer promotion.
The (uint32_t)/(uint64_t) casts ensure the values are properly truncated no matter the size of an int.
Prior to this commit, if secp256k1_ctz32_var_debruijn were some how managed to be built on a platform with 64-bit ints, (though this function is specifically only intended to be used on 32-bit platforms) it would perform an out-of-bounds array access.