Extremely large transactions with lots of inputs can cost the network almost as much to process as they cost the sender in fees.
We would never create transactions larger than 100K big; this change makes transactions larger than 100K non-standard, so they are not relayed/mined by default. This is most important for miners that might create blocks larger than 250K big, who could be vulnerable to a make-your-blocks-so-expensive-to-verify-they-get-orphaned attack.