Spawning threads prior to __AFL_INIT is not supported as the afl++ fork server can't clone threads, see afl++ docs.
We however have chosen to do this in several of our targets (e.g. process_message, process_messages) and as a result those targets can not be fuzzed using afl++ (resulting in timeouts). Afaict this is only a problem if the spawned threads are also used (e.g. join) in the target.
A potential fix would be to call initialize after __AFL_INIT but prior to __AFL_LOOP, which will however lead to slower fuzzing for all targets.
(I'm uncertain why oss-fuzz does not report the timeouts to us but that seems like an issue on their end)