The LLD wrapper aims to add any missing -rpath flags. However, this is only required for native binaries, and is already handled by the native toolchain (currently gcc-toolchain-14).
Based on my testing, it wasn’t necessary in the original #21778.
My Guix build for macOS targets (on both x86_64 and aarch64 platforms):
0ebb020db55591ed1b85b5d64145a658032879b8641cde43c259cae3e6abc19db guix-build-b849d6c51815/output/arm64-apple-darwin/SHA256SUMS.part
1798596beec8e473519d8b512cd6d178d1bce9e9a9e89d955844df0c89853be41 guix-build-b849d6c51815/output/arm64-apple-darwin/bitcoin-b849d6c51815-arm64-apple-darwin-codesigning.tar.gz
2efe3cc64e3d5ca76fa96d1faa39d7411989feb7fb285eed212675bd7e9309552 guix-build-b849d6c51815/output/arm64-apple-darwin/bitcoin-b849d6c51815-arm64-apple-darwin-unsigned.tar.gz
39f468c9c005d0a13a2a3b876a5f9a92770d08a63b8e19e1d76f123947773fd77 guix-build-b849d6c51815/output/arm64-apple-darwin/bitcoin-b849d6c51815-arm64-apple-darwin-unsigned.zip
4e81d27c3e74ea43ce812f392af50400bd6988b8fc6cee4c5e61d225724cc0552 guix-build-b849d6c51815/output/dist-archive/bitcoin-b849d6c51815.tar.gz
58b20cd54087c9a0651e938ffb61d60e18cd90219928e168e7f96c1c3756bb751 guix-build-b849d6c51815/output/x86_64-apple-darwin/SHA256SUMS.part
60ae6cd4889f5c2922caa792cc0db13c5ba41c0fe0dc1c3de1624840ce9cd732e guix-build-b849d6c51815/output/x86_64-apple-darwin/bitcoin-b849d6c51815-x86_64-apple-darwin-codesigning.tar.gz
72c5a6fdf7a57ff2fb1a5ed0a58db24f9862b4a6c030118352555f6a4fc32d936 guix-build-b849d6c51815/output/x86_64-apple-darwin/bitcoin-b849d6c51815-x86_64-apple-darwin-unsigned.tar.gz
89039796aaf9228c20215831e95c4fe8024a50bfee809608e9185c0ba4d18ac21 guix-build-b849d6c51815/output/x86_64-apple-darwin/bitcoin-b849d6c51815-x86_64-apple-darwin-unsigned.zip
Split from #32764.