It doesn't make sense for the release binaries to contain references to depends, either in debug symbols, or in relation to runtime functionality, as it's unlikely that "depends" exists on a users system at runtime.
There are a number of Qt (and sub dep) related changes here. Not completely sure what is the best approach for these. My current understanding is that most of these changes should be a no-op at runtime.
Should avoid depends paths ending up in Guix binaries:
/bitcoin/depends/x86_64-linux-gnu/share/X11/xkb
~/.local/share/icons:~/.icons:/bitcoin/depends/x86_64-linux-gnu/share/icons:/bitcoin/depends/x86_64-linux-gnu/share/pixmaps
qt_prfxpath=/bitcoin/depends/x86_64-linux-gnu
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