It would be nice if guix was arch agnostic, so different archs can be used to get the same binary.
I tried running guix on amd64 and arm64, for the target bitcoin-62cc2180afc1-powerpc64le-linux-gnu.tar.gz
and only got a few bits difference:
0--- ./bitcoin-arm64/bin/bitcoin-cli
1+++ ./bitcoin-amd64/bin/bitcoin-cli
2├── readelf --wide --decompress --hex-dump=.gnu_debuglink {}
3│ @@ -1,5 +1,5 @@
4│
5│ Hex dump of section '.gnu_debuglink':
6│ 0x00000000 62697463 6f696e2d 636c692e 64626700 bitcoin-cli.dbg.
7│ - 0x00000010 13a837f9 ..7.
8│ + 0x00000010 08b973c6 ..s.